Open Access Research article

RNA sequencing revealed novel actors of the acquisition of drug resistance in Candida albicans

Sanjiveeni Dhamgaye1, Maria Bernard345, Gaelle Lelandais6, Odile Sismeiro7, Sophie Lemoine345, Jean-Yves Coppée7, Stéphane Le Crom345, Rajendra Prasad1* and Frédéric Devaux28

Author Affiliations

1 Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India

2 UPMC, UMR7238, Génomique des Microorganismes, 15 rue de l'École de Médecine, 75006, Paris, France

3 Ecole Normale Supérieure, Institut de Biologie de l´ENS, IBENS, Paris, F-75005, France

4 Inserm, U1024, Paris, F-75005, France

5 CNRS, UMR 8197, Paris, F-75005, France

6 Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB), INTS, Université Paris Diderot, Sorbonne Paris Cité, INSERM, U665, Paris, France

7 Institut Pasteur, Plate forme Transcriptome et Epigenome, Departement Genomes et Genetique, Paris, France

8 CNRS, UMR7238, Génomique des Microorganismes, Paris, France

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BMC Genomics 2012, 13:396  doi:10.1186/1471-2164-13-396

Published: 16 August 2012

Additional files

Additional file 1 :

Table S1. Genes with enlarged 3' or 5' UTR boundaries as compared with the annotation of Bruno et al. 2010. Table S2. annotation and coordinates of new transcripts found based on our RNA seq data. Overlap with previously annotated transcripts are indicated (annotations taken from Candida Genome Database, Bruno et al., 2010; Sellam et al., 2010 and Tuch et al., 2010). Table S3. CDR Induced genes. Genes that were found significantly overexpressed in Gu5 by Deseq and EdgeR. Log2(ratios) are indicated, together with CGD descriptions. The CDR isolates column indicate the number of different isolates in which the gene was previously found to be overexpressed, based on the studies of Liu et al., 2007 and Znaidi et al., 2006. Table S4. List of the strains used in the study. Table S5. Sequences of the primers used in the study.

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