Table 3

Histopathological observations/changes
Organ Changes PP MP P-value*
Liver No significant findings 39.0% 33.3% 0.39
Mild fatty change 38.1% 31.4% 0.312
Mild to moderate fatty change 8.6% 7.6% 0.801
Moderate fatty change 8.6% 8.6% n.d.
Moderate to severe fatty change 0.0% 1.9% 0.156
Severe fatty change 0.0% 0.0% n.d.
Perivascular infiltration 2.9% 6.7% 0.196
Peri biliar ducts infiltration 3.8%a 21.0% <0.001
Necrotic foci w/infiltration 1.0% 0.0% 0.317
Mild congestion 0.0% 1.0% 0.317
Focal necrosis 0.0% 2.9% 0.082
Mild sinusoidal dilatation 0.0% 1.0% 0.317
Biliar ducts esclerosis 0.0% 2.9% 0.082
Biliar ducts proliferation 0.0% 0.0% n.d.
Foci of inflammatory cells 0.0% 1.0% 0.317
Heart (ventricle) No significant findings 99.0% 98.1% 0.562
Severe infiltration and myodegeneration 1.0% 1.0% n.d.
Infiltration, no myodegeneration 0.0% 1.0% 0.317
Presence of melanin granules 0.0% 0.0% n.d.
Mid-intestine and Pyloric caeca No significant findings 100% 100% n.d.
Distal intestine No significant findings 97.1% 95.2% 0.472
Infiltration of submucosa and lamina propria, widened of lamina propria within folds (simple and complex), prominent goblet cells/low number of supranuclear vacuoles 2.9% 4.8% 0.472

Histopathological observations/changes. Values (in percentage) represent occurrence where nā€‰=ā€‰105. Significantly different when Pā€‰<ā€‰0.05, different superscript letters indicate significant differences within each row-wise comparison.

Tacchi et al.

Tacchi et al. BMC Genomics 2012 13:363   doi:10.1186/1471-2164-13-363

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