Table 1

miRNAs most preferentially released into EVs
miRNA Non-transfected cells & EVs miR-146a - Transfected cells & EVs
RPMM cells RPMM EV Log2(EV/Cells) RPMM cells RPMM EV Log2(EV/Cells)
mir-451 0.4 3945.0 13.3 1.7 7982.5 12.2
mir-150 0.4 2475.0 12.6 0.3 663.0 10.9
mir-146a* 10.4 1321.2 7.0 317863.3* 440496.3* 0.5
mir-320c 24.3 2347.5 6.6 57.8 1803.4 5.0
mir-143 39.9 3232.5 6.3 8327.3 354.4 8.5
mir-720 65.4 3157.5 5.6 3208.9 46.2 5.5
mir-125a-5p 214.7 9360.0 5.4 439.0 2121.6 2.3
mir-486 105.7 3900.0 5.2 72.8 7637.8 6.7
mir-149 89.0 3142.5 5.1 85.3 928.2 3.4
mir-2110 43.5 1380.0 5.0 175.0 928.2 2.4
mir-320a 762.1 23190.0 4.9 1250.0 11483.2 3.2
mir-197 472.4 8347.5 4.1 724.0 6046.6 3.1
mir-339 91.4 1515.0 4.1 178.0 610.0 1.8
mir-99b 2065.2 27420.0 3.7 4900.0 8353.8 0.8
mir-4286 108.5 1245.0 3.5 72.1 1617.7 4.5
mir-92b 515.1 5542.5 3.4 484.0 4800.1 3.3
mir-222 774.1 7882.5 3.3 1200.0 10634.5 3.1
mir-423-5p 5737.2 55762.5 3.3 5290.0 22435.9 2.1
mir-877 467.2 4425.0 3.2 2000.0 2121.6 0.1
mir-191 9501.8 88717.5 3.2 15000.0 40893.8 1.4
mir-1292 140.0 1222.5 3.1 256.0 397.8 0.6
mir-1246 782.8 6570.0 3.1 156.0 11456.6 6.2

Those miRNAs represented by at least 1000 reads in either cells or EV are listed. * For the transfected cells and EVs the RPMM values were calculated after removal of the reads from over-expressed miR-146a, to facilitate comparison with non-transfected samples (the RPMM values shown for miR-146a are those prior to this normalisation).

Guduric-Fuchs et al.

Guduric-Fuchs et al. BMC Genomics 2012 13:357   doi:10.1186/1471-2164-13-357

Open Data