MSTNis highly differentially co-expressed with many of the abundant, highly differentially expressed genes - mutant breed on the left, wildtype breed on the right. For example, MSTN has a differential co-expression of 1.1 (+0.76 - - 0.34) with MYL2 (Panel A). RIF accumulates these differential co-expressions for all the DE genes (85 in this instance), weighted by their abundance. The size of the bubble representing the various DE genes corresponds to the combination of the extent of DE and average abundance. An alternative measure of differential connectivity is given in Panel B, where the number of significant co-expressions possessed by MSTN in the two breeds is contrasted. MSTN does not get prioritised by this alternative approach.
Hudson et al. BMC Genomics 2012 13:356 doi:10.1186/1471-2164-13-356