Integrin signaling pathway and its interaction as a radiosensitive target. A. Statistical ranking of pathways with the commonly selected 179 genes using SAM analysis. The x-axis displays the -log of the p-value calculated by Fisher's exact test, right-tailed. B. Gene plot showing the influence of individual genes of the integrin signaling pathway produced by a global test. The influence on the y-axis is represented as the p-value, the extent of correlation between SF2 (radiosensitivity) and gene expression in a gene set. A lower p-value means that the gene is well correlated between SF2 and the gene expression value. C. Integrin signaling pathway interaction with identified adhesion molecules from the 31 radiosensitivity signature. (References from Ingenuity knowledge base, Additional file 6).
Kim et al. BMC Genomics 2012 13:348 doi:10.1186/1471-2164-13-348