Table 4

Annotation clusters affected by lead in individuals with high blood lead levels
Annotation Cluster 1 Enrichment Score: 4.6
Category Term Count P-value FDR
GOTERM_BP_FAT GO:0010941 ~ regulation of cell death 84 2.05E-05 0.04
GOTERM_BP_FAT GO:0042981 ~ regulation of apoptosis 83 2.21E-05 0.04
GOTERM_BP_FAT GO:0043067 ~ regulation of programmed cell death 83 3.15E-05 0.06
Annotation Cluster 2 Enrichment Score: 4.4
Category Term Count P-value FDR
GOTERM_BP_FAT GO:0010629 ~ negative regulation of gene expression 59 1.24E-05 0.02
GOTERM_BP_FAT GO:0016481 ~ negative regulation of transcription 55 1.33E-05 0.02
GOTERM_BP_FAT GO:0010558 ~ negative regulation of macromolecule biosynthetic process 62 1.97E-05 0.04
GOTERM_BP_FAT GO:0031327 ~ negative regulation of cellular biosynthetic process 63 2.22E-05 0.04
GOTERM_BP_FAT GO:0009890 ~ negative regulation of biosynthetic process 64 2.23E-05 0.04
GOTERM_BP_FAT GO:0045934 ~ negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 57 7.26E-05 0.13
GOTERM_BP_FAT GO:0051172 ~ negative regulation of nitrogen compound metabolic process 57 1.05E-04 0.19
GOTERM_BP_FAT GO:0010605 ~ negative regulation of macromolecule metabolic process 71 6.31E-04 1.14
Annotation Cluster 3 Enrichment Score: 4.0
Category Term Count P-value FDR
GOTERM_BP_FAT GO:0043068 ~ positive regulation of programmed cell death 50 9.01E-05 0.16
GOTERM_BP_FAT GO:0010942 ~ positive regulation of cell death 50 1.00E-04 0.18
GOTERM_BP_FAT GO:0043065 ~ positive regulation of apoptosis 49 1.47E-04 0.27
Annotation Cluster 4 Enrichment Score: 3.8
Category Term Count P-value FDR
GOTERM_BP_FAT GO:0016481 ~ negative regulation of transcription 55 1.33E-05 0.02
GOTERM_BP_FAT GO:0045892 ~ negative regulation of transcription, DNA-dependent 41 4.50E-04 0.81
GOTERM_BP_FAT GO:0051253 ~ negative regulation of RNA metabolic process 41 6.25E-04 1.13

Gillis et al.

Gillis et al. BMC Genomics 2012 13:344   doi:10.1186/1471-2164-13-344

Open Data