Table 1

Top 25 GO categories overrepresented in LI of 0WexGF mice compared with GF mice
GOID Term Number of Probes p_int
GO:0042254 ribosome biogenesis and assembly 92 < 1.0E-18
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 14 6.18E-08
GO:0048511 rhythmic process 19 1.16E-07
GO:0006954 inflammatory response 48 6.79E-07
GO:0030300 regulation of cholesterol absorption 5 1.09E-06
GO:0006610 ribosomal protein import into nucleus 10 1.61E-06
GO:0042157 lipoprotein metabolic process 8 2.00E-06
GO:0001558 regulation of cell growth 64 2.63E-06
GO:0007166 cell surface receptor linked signal transduction 50 2.68E-06
GO:0050766 positive regulation of phagocytosis 10 3.64E-06
GO:0060048 cardiac muscle contraction 11 5.07E-06
GO:0007417 central nervous system development 17 6.65E-06
GO:0007413 axonal fasciculation 8 1.32E-05
GO:0006911 phagocytosis, engulfment 7 1.52E-05
GO:0006310 DNA recombination 27 1.54E-05
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 6 2.46E-05
GO:0006950 response to stress 30 2.84E-05
GO:0000165 MAPKKK cascade 21 3.24E-05
GO:0007585 respiratory gaseous exchange 12 3.92E-05
GO:0006816 calcium ion transport 44 4.33E-05
GO:0042593 glucose homeostasis 18 5.19E-05
GO:0006414 translational elongation 14 5.69E-05
GO:0030901 midbrain development 8 6.54E-05
GO:0045582 positive regulation of T cell differentiation 6 7.88E-05
GO:0007229 integrin-mediated signaling pathway 36 8.14E-05

MGP analysis was performed on GO BP categories which contains 4 ~ 99 genes (“Number of Probes”). The categories were sorted according to the integrated p value (p_int) and the top 25 are represented. The categories related to antigen presentation are noted (e.g., “antigen processing and presentation of exogenous peptide antigen via MHC class II”, “inflammatory response”, “positive regulation of phagocytosis”, “phagocytosis, engulfment”, “antigen processing and presentation of peptide or polysaccharide antigen via MHC class II” and “positive regulation of T cell differentiation”).

Yamamoto et al.

Yamamoto et al. BMC Genomics 2012 13:335   doi:10.1186/1471-2164-13-335

Open Data