Metabolic map of breast cancer showing alterations in energy metabolism, catabolism of amino acids, nucleotide metabolism and other pathways. Networks were generated using Cytoscape with the Metscape plug-in. Significantly increased metabolites in tumor compared to normal tissue (red nodes), significantly decreased metabolites (green nodes), unchanged metabolites (yellow nodes) and metabolites not in the GC-TOFMS screen (white nodes). The size of the nodes is proportional to the absolute value of the fold change.
Budczies et al. BMC Genomics 2012 13:334 doi:10.1186/1471-2164-13-334