Impact of liver development on xenobiotic metabolism gene expression. A.Canonical pathways involved in xenobiotic metabolism. Scale is described in Figure 2. B. Expression of Cyp genes. C. Expression of phase II conjugating genes. D. Expression of phase III transporter genes. Right, detail of up-regulated transporter genes. Arrowheads indicate genes identified as being bone marrow-specific and thus may originate from extrahepatic cells. E. Expression of nuclear receptors during development including those that regulate xenobiotic metabolism.
Lee et al. BMC Genomics 2012 13:33 doi:10.1186/1471-2164-13-33