Table 2

Flux distributions as a function of NADPH demand
Acetoin (mM) 0 100 200 300
Glucose uptake (mmol/gDW/h) 17.8 19.5 19.6 25.7
Glycolysis 84.7 ± 0.9 78.8 ± 1.9 69.9 ± 0.6 65.2 ± 0.6
PPP 11.4 ± 0.9 18 ± 1.9 26 ± 0.9 33.0 ± 1.4
Transketolase 5.6 ± 1.5 9.0 ± 2.5 12.2 ± 2.7 18.6 ± 4.2
Biomass (Carbohydrates) 3.3 ± 0.1 3.4 ± 0.1 2.5 ± 0.1 2.1 ± 0.1
Pyruvate decarboxylase 164.3 ± 0.1 164.8 ± 0.5 167.1 ± 0.1 167.9 ± 0.4
Pyruvate carboxylase 4.2 ± 0.8 2.7 ± 0.7 2.1 ± 0.6 2.5 ± 0.6
Import of oxaloacetate into the mitochondria 3.4 ± 0.8 2 ± 0.7 1.6 ± 0.6 2 ± 0.6
Acetaldehyde dehydrogenase 2.4 ± 0.1 3.8 ± 0.06 4.2 ± 0.1 5.6 ± 0.1
Biomass (Lipids) 0.29 ± 0.01 0.17 ± 0.02 0.15 ± 0.02 0.09 ± 0.04
Acetyl-CoA synthetase 0.30 ± 0.03 0.20 ± 0.06 0.22 ± 0.1 0.13 ± 0.09
Ethanol production 161.9 ± 0.1 161 ± 0.5 162.9 ± 0.5 162.3 ± 0.5
Glycerol production 17.8 ± 0.1 17.9 ± 0.1 14.7 ± 0.1 13.7 ± 0.1
Acetate production 2.1 ± 0.1 3.6 ± 0. 1 4.0 ± 0. 1 5.5 ± 0.1
Succinate production 0.30 ± 0.01 0.26 ± 0. 01 0.26 ± 0. 01 0.28 ± 0. 01

Celton et al.

Celton et al. BMC Genomics 2012 13:317   doi:10.1186/1471-2164-13-317

Open Data