Table 6

Conserved and Divergent Metabolic Pathways

Most conserved

p-value

Most divergent

p-value


1-icosatrienoyl-sn-glycero-3-phosphocholine pathway

6.01E-03

(L)-leucine pathways and transport

2.42E-03


1-docosahexaenoyl-glycerol_3-phosphocholine pathway

6.96E-03

GalNAcbeta1-3Gal pathway

3.06E-03


2-arachidonoyl-glycerol_3-phosphocholine pathway

8.16E-03

Branched-chain amino acid metabolism

4.08E-03


Phosphatidylinositol-3,4,5-triphosphate pathway

1.61E-02

Estrone and Estradiol metabolism

2.23E-02


[O-hexadecanoyl-(L)-carnitine pathway

2.10E-02

N-acyl-sphingosine phosphate pathway

2.48E-02


Phosphatidylinositol-4,5-diphosphate pathway

3.18E-02

HETE, HPETE and Leukotriene4 metabolism

6.47E-02


Glutamic acid pathway

3.83E-02

Tryptophan, Phenylalanine, Methionine metabolism

7.02E-02


L-glutamate pathways and transport

5.94E-02

Tryptophan, Phenylalanine, Tyramine, Methionine metabolism and transport

8.30E-02


Glycolysis, Glucogenesis and glucose transport

6.26E-02

Lyso-Phosphatidylserine pathway

8.88E-02


Glutamic acid pathways and transport

6.83E-02

Cholesterol biosynthesis

1.13E-01


The ten most highly conserved, and the ten most highly divergent metabolic pathways are listed along with the p-value for each pathway. The most conserved pathways are associated with the lowest dN/dS values, whereas the most divergent pathways are associated with the highest dN/dS values.

Irizarry et al. BMC Genomics 2012 13:31   doi:10.1186/1471-2164-13-31

Open Data