Understanding causes of poor model fit. A) GOF statistics for genes with an average count per subject <5 are shown in red on the QQ plot from NB, locally estimated variance with no blocking factor models. B) Dot plot demonstrating the large variance in a gene with an extremely large GOF statistic.
Oberg et al. BMC Genomics 2012 13:304 doi:10.1186/1471-2164-13-304