Table 5

Comparative analysis of D. japonica CNS development genes with S. mediterranea and the schistosoma
GO Term D. japonicaUnigenes UniProt KB Homology UniProt E-value S. mediterranea Schistosoma
Genome mRNA Genome mRNA
ventral cord development Dj_CL2868_001_b2 Protein numb 2.00E-68 + + + +
Dj_CL0775_001_b2 Ras-related protein Rac1 2.00E-85 + + + +
Dj_aH_314_P04.full Protein nubbin 7.00E-21 + + +
Dj_aH_000_00626HN.full Zinc finger protein jing 1.00E-12 + + +
brain development Dj_CL0266_002_b2 Dynein heavy chain, cytoplasmic 0.00E + 00 + + + +
Dj_aH_323_P16 DNA topoisomerase 2-beta 1.00E-129 + + + +
Dj_CL2992_001_b2 Probable global transcription activator SNF2L1 1.00E-104 + + + +
Dj_CL0800_001_b2 Transcriptional regulator ATRX 5.00E-84 + + + +
Dj_aH_133136_J24 Myosin-10 2.00E-80 + + + +
Dj_CL1927_001_b2 Protein Wnt-4 3.00E-62 + + + +
Dj_CL1142_001_b2 Brain tumor protein 5.00E-35 + + + +
Dj_CL2438_001_b2 Ubiquitin carboxyl-terminal hydrolase isozyme L5 3.00E-72 + + + +
Dj_CL1575_001_b2 Alpha-soluble NSF attachment protein 1.00E-77 + + + +
Dj_aH_121124_O06 cGMP-dependent protein kinase 1 4.00E-81 + + + +
Dj_aH_203_F09 Neurofibromin 2.00E-40 + + + +
Dj_aH_517_H15.double Receptor tyrosine-protein kinase erbB-4 3.00E-83 + + + +
Dj_aH_526_D23.double Hypoxanthine-guanine phosphoribosyltransferase 4.00E-61 + + + +
Dj_aH_214_D06.full Homeobox protein SIX3 2.00E-90 + + + +
Dj_aH_202_C21 Plasma membrane calcium-transporting ATPase 3 8.00E-47 + + + +
Dj_CL0788_001_b2 Neural cell adhesion molecule 1 5.00E-18 + + + +
Dj_aH_204_E12 Protein kinase C iota type 1.00E-49 + + + +
Dj_CL3335_001_b2 Nuclear factor 1 B-type 4.00E-14 + + + +
Dj_aH_307_L04.rev cGMP-dependent protein kinase 1 8.00E-55 + + + +
Dj_CL3457_001_b2 RNA binding protein fox-1 homolog 1 5.00E-33 + + + +
Dj_CL1765_001_b2 Zinc finger protein ZIC 2 2.00E-73 + + + +
Dj_aH_503_H01 Epidermal growth factor receptor 9.00E-38 + + + +
Dj_aH_511_L17 Tubby-related protein 3 2.00E-44 + + + +
Dj_CL1678_001_b2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 2.00E-35 + + + +
Dj_CL2162_001_b2 Menin 1.00E-37 + + + +
Dj_CL3785_001_b2 Excitatory amino acid transporter 2 5.00E-28 + + + +
Dj_aH_514_N16 DNA topoisomerase 2-beta 2.00E-33 + + + +
Dj_aH_325_L12.double Paired mesoderm homeobox protein 2B 2.00E-28 + + + +
Dj_aH_305_P01 Transcriptional regulator ATRX 9.00E-29 + + + +
Dj_aH_520_E14 Epidermal growth factor receptor 9.00E-15 + + + +
Dj_aH_000_01325HH.double NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 1.00E-24 + + + +
Dj_aH_217_D18 Cysteine string protein 7.00E-28 + + + +
Dj_aH_402_H01 LIM homeobox transcription factor 1-alpha 2.00E-29 + + + +
Dj_CL3423_001_b2 Lethal(2) giant larvae protein homolog 1 2.00E-14 + + + +
Dj_aH_222_K23 Leishmanolysin-like peptidase 2.00E-38 + + + +
Dj_aH_505_J10 Ski oncogene 1.00E-32 + + + +
Dj_aH_519_D15.double Bardet-Biedl syndrome 2 protein homolog 4.00E-51 + + + +
Dj_CL0001_086_b2 Paired box protein Pax-6 5.00E-72 + + + +
Dj_CL3673_001_b2 Glutamate [NMDA] receptor subunit epsilon-1 2.00E-37 + + + +
Dj_aH_000_04532HH.full Protocadherin-18 3.00E-39 + + +
Dj_aH_523_G03.rev Tubby-related protein 3 4.00E-23 + + + +
Dj_CL1956_001_b2 Homeobox protein meis3-A 3.00E-44 + + + +
Dj_CL1514_001_b2 Protocadherin-like wing polarity protein stan 2.00E-20 + + + +
Dj_CL2141_001_b2 Large proline-rich protein BAG6 2.00E-11 + + + +
Dj_aH_306_A21 Sphingosine kinase 2 3.00E-14 + + +
Dj_CL3244_001_b2 Neuroligin-4, X-linked 1.00E-21 + + +
Dj_CL4115_001_b2 Neuroglian 2.00E-41 + + +
Dj_aH_306_H01 Protein phosphatase Slingshot 6.00E-14 + + +
Dj_CL1452_001_b2 SH3 and multiple ankyrin repeat domains protein 2 3.00E-18 + + +
Dj_CL1757_001_b2 Intraflagellar transport protein 88 homolog 4.00E-74 + + +
Dj_aH_527_L21 Cytosolic carboxypeptidase 1 3.00E-76 + + +
Dj_aH_522_B06 Slit homolog 2 protein (Fragment) 7.00E-15 + + +
Dj_aH_137140_C22 Bardet-Biedl syndrome 4 protein 6.00E-47 + + +
Dj_aH_303_K17 Zinc finger protein Dzip1 1.00E-33 + + +
Dj_aH_207_O05 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 8.00E-88 + + +
Dj_CL0854_001_b2 Secreted frizzled-related protein 5 3.00E-29 + + +
Dj_CL3133_001_b2 Cytosolic carboxypeptidase 1 3.00E-35 + + +
Dj_aH_313_M09.double Cyclin-dependent kinase 5 activator 1 2.00E-48 + + +
Dj_CL0876_001_b2 Sodium/calcium exchanger 1 1.00E-161 + + +
Dj_aH_303_F09 Frizzled-8 1.00E-21 + + +
Dj_CL4143_001_b2 Intraflagellar transport protein 88 homolog 2.00E-81 + + +
Dj_aH_530_O19 Paired box protein Pax-6 9.00E-55 + + +
Dj_aH_007_F21 Protein Hook homolog 3 6.00E-13 + +
Dj_aH_309_N15.double Dixin 6.00E-11 + +
Dj_CL4393_001_b2 Endothelin-converting enzyme 2 7.00E-34 + +
Dj_aH_325_L06 Centrosomal protein of 290 kDa 3.00E-31 + +
Dj_CL0234_001_b2 Reticulon-4 2.00E-13 + +
Dj_aH_518_F04.double Ceroid-lipofuscinosis neuronal protein 5 2.00E-74 + +
spinal cord development Dj_aH_203_F09 Neurofibromin 2.00E-40 + + + +
Dj_aH_000_02581HH Calpain-A 1.00E-51 + + + +
Dj_aH_502_D11 Calpain-A 2.00E-67 + + + +
Dj_aH_511_L17 Tubby-related protein 3 2.00E-44 + + + +
Dj_CL3713_001_b2 Suppressor of fused homolog 2.00E-21 + + + +
Dj_aH_000_01210HH.full Suppressor of fused homolog 3.00E-15 + + + +
Dj_CL3673_001_b2 Glutamate [NMDA] receptor subunit epsilon-1 2.00E-37 + + + +
Dj_aH_523_G03.rev Tubby-related protein 3 4.00E-23 + + + +
Dj_aH_522_B06 Slit homolog 2 protein (Fragment) 7.00E-15 + + +
Dj_aH_000_03614HH DNA-binding protein SMUBP-2 4.00E-23 + +
central nervous system  neuron differentiation Dj_CL2485_001_b2 Spastin 1.00E-83 + + + +
Dj_aH_526_D23.double Hypoxanthine-guanine phosphoribosyltransferase 4.00E-61 + + + +
Dj_aH_511_L17 Tubby-related protein 3 2.00E-44 + + + +
Dj_aH_402_H01 LIM homeobox transcription factor 1-alpha 2.00E-29 + + + +
Dj_aH_523_G03.rev Tubby-related protein 3 4.00E-23 + + + +
Dj_aH_527_L21 Cytosolic carboxypeptidase 1 3.00E-76 + + +
Dj_CL3133_001_b2 Cytosolic carboxypeptidase 1 3.00E-35 + + +
Dj_aH_000_03614HH DNA-binding protein SMUBP-2 4.00E-23 + +
astrocyte differentiation Dj_aH_203_F09 Neurofibromin 2.00E-40 + + + +
Dj_CL0341_002_b2 Porphobilinogen deaminase 4.00E-69 + + + +
Dj_CL0341_001_b2 Porphobilinogen deaminase 2.00E-64 + + + +
oligodendrocyte differentiation Dj_aH_203_F09 Neurofibromin 2.00E-40 + + + +
Dj_aH_513_H15.rev Exocyst complex component 4 7.00E-18 + + + +
Dj_CL1495_001_b2 Translation initiation factor eIF-2B subunit delta 4.00E-42 + + + +

+ indicate the presence of gene which homologous with D. japonica CNS-development gene in S. mediterranea and the schistosoma.

Nishimura et al.

Nishimura et al. BMC Genomics 2012 13:289   doi:10.1186/1471-2164-13-289

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