Open Access Research article

Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

Hao Hu1, Pradip K Bandyopadhyay2, Baldomero M Olivera2 and Mark Yandell1*

Author Affiliations

1 Eccles institute of Human Genetics, University of Utah, and School of Medicine, Salt Lake City, UT, 84112, USA

2 Department of Biology, University of Utah, Salt Lake City, UT, 84112, USA

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BMC Genomics 2012, 13:284  doi:10.1186/1471-2164-13-284

Published: 28 June 2012

Additional files

Additional file 1: Figure S1.:

iPath (a) regulatory pathway map and (b) secondary-metabolite biosynthesis pathway map. Each grey dot represents a substrate and each red line represents an enzyme.

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Additional file 2: Table S1.:

A list of complete conotoxins sequences identified in the venom duct. The expression levels are shown for each conotoxin in each segment, represented as number of reads aligned to the toxin. Toxins are numbered G1-63, and have been listed according to their superfamilies. In the A superfamily, (X,Y) refers to the number of amino acid residues in the first and second disulfide loops. G4.x is the commonly used nomenclature of alpha-A family of conotoxins identified from Conus geographus. Other designations in parenthesis adjacent to GX indicate previously used nomenclature in the literature [3,4,12,49-55].

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Additional file 3: Table S2.:

InterPro protein families differentially expressed among the four segments Proximal (P), Proximal Central (PC), Distal Central (DC) and Distal (D), showing the proportion of aligned reads among whole transcriptome [[3],[4],[12],[49-55]].

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Additional file 4: Table S3.:

Comparison of toxin sequences of αA-OIVA, a fetal muscle nicotinic acetylcholine receptor antagonist, with G10 4.1 and G11 4.2 [[3],[4],[12],[49-55]].

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