Table 2

CD-epitope cores derived from γ-gliadins
epitope new epitope nomenclature** 9-mer core
DQ2-γ-VIIb3* DQ2.5-glia-γ4c
    Q
QP
    Q
QPFPQ
DQ2-γ-VI3 DQ2.5-glia-γ5
    Q
QPFP
    Q
QPQ
DQ2.5-glia-γ2a6 x FP
    Q
QP
    Q
QPF
DQ2-γ-II(Glia γ30)3,4 DQ2.5-glia-γ2 IQP
    Q
QPAQL
DQ2-γ-I (Glia-γ1)2 DQ2.5-glia-γ1 P
    Q
QSFPQQ
    Q
DQ2-γ-VIIa3 DQ2.5-glia-γ4b PQP
    Q
Q
    Q
FPQ
DQ2-γ-IV5 DQ2.5-glia-γ4a SQP
    Q
Q
    Q
FPQ
DQ2-γ-III5* DQ2.5-glia-γ3
    Q
QP
    Q
QPYP
    Q
DQ2-glia-γ2b6 x YP
    Q
QP
    Q
QPF

CD-epitope cores (9-mer binding cores) derived from γ-gliadins. The targets for tTG deamidation are depicted in

. 2Sjöström et al. [17], 3Qiao et al.[7], 4Vader et al.[22], 5Arentz-Hansen et al [19], 6Stepniak et al.[21]. *deamidation dependent epitope, QP QPF/YP , deamidation at position 4 is HLA-DQ2 restricted and deamidation at positions 1 and 9, QP QP(F/Y)P is HLA-DQ8 [8]; the same counts for DQ2-γ-VI ( QPFP QP ), in case of deamidation at P1 and P9 this epitope is HLA-DQ8 restricted [9]. ** Nomenclature and listing of celiac disease relevant gluten T-cell epitopes (Sollid et al. [55]).

Salentijn et al.

Salentijn et al. BMC Genomics 2012 13:277   doi:10.1186/1471-2164-13-277

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