TF binding differences between CRMs at differentially expressed genes. (A) Dissimilarity of TF binding sites at the promoters of genes which are under-expressed and over-expressed in GM12878 compared to K562. We compared the enrichment (observed/expected numbers) of TFs that bind to CRMs in GM12878 but not in K562 (black bars) and TFs that bind to CRMs in K562 but not in GM12878 (white bars). (B) Hierarchical clustering of TFs based on co-occurrence at promoters of the differentially expressed genes. TFs are clustered closer together if their binding sites co-localize more often in the CRMs of K562 and GM12878.
Wang et al. BMC Genomics 2012 13:263 doi:10.1186/1471-2164-13-263