Distribution of dissimilar CRMs at differentially expressed genes. The dissimilarity between CRMs at the promoter regions of all genes (red bars) and at the promoter regions of differentially expressed genes (blue bars) are compared to the dissimilarity between randomly generated CRMs (green bars with 95% confidence intervals). Dissimilarity between an overlapping pair of CRMs is described by the number of different TFs (Hamming distance) bound to a K562 CRM compared to a GM12878 CRM.
Wang et al. BMC Genomics 2012 13:263 doi:10.1186/1471-2164-13-263