sfrp2 RNA levels are disturbed in Hh pathway mutants and after pharmacological treatments. (A, A'') In WT embryos, sfrp2 expression is evident in adaxial cells. This expression is significantly down-regulated in yot embryos (B, B''). Pharmacological treatments with pur and cyc show altered expression in pharyngeal arches (asterisk in E, compare C, D and E for different levels of RNA). Anterior is towards left, lateral views are shown. Full lateral views of embryos are shown in A' and B'.
Milla et al. BMC Genomics 2012 13:2 doi:10.1186/1471-2164-13-2