Table 3

Priming-related modulation of gene expression subsequent to an E. coli challenge after a short waiting period

Symbol

Entrez Gene Name

Mean ratio

Mean ratio compared to

un-stimulated control (C.)

Expression regulated by****

I.p.P/I.

I.p.P./C.

I./C.

P./C.

IL1

TNF

IL6

IRF7


Priming provokes a higher the expression level after an E. coli challenge of:

CORO1A*

coronin, actin binding protein, 1A

2.8**

2***

-2

2

CD55

CD55 molecule, decay accelerating factor for complement

2.6

2

-2

2

x

x

HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

2.3

4

2

4

x

TGM3

transglutaminase 3

2.3

4

2

2

SLPI

secretory leukocyte peptidase inhibitor

2.2

5

2

4

x

LY6G6E

lymphocyte antigen 6 complex, locus G6E

2.2

2

NC

2

CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

2.1

NC

-2

2

DEFB4A

defensin, beta 4A

2.1

47

22

24

x

x

HLA-DRA

major histocompatibility complex, class II, DR alpha

2.1

6

3

6

x

ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4

2.0

NC

-2

NC

Priming provokes a lower expression level after an E. coli challenge of:

NOS2

nitric oxide synthase 2, inducible

-10.7

14

154

NC

x

x

x

GBP2

guanylate binding protein 2, interferon-inducible

-8.1

36

287

10

x

x

x

APOL3

apolipoprotein L, 3

-7.9

4

30

NC

IL1B

interleukin 1, beta

-6.4

5

32

NC

x

x

TIFA

TRAF-interacting protein with forkhead-associated domain

-6.0

6

36

NC

TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

-5.8

15

89

NC

x

x

TMEM140

transmembrane protein 140

-5.8

2

11

NC

GBP4

guanylate binding protein 4

-5.8

NC

6

NC

x

x

LMO2

LIM domain only 2 (rhombotin-like 1)

-5.3

NC

5

NC

RTP4

receptor (chemosensory) transporter protein 4

-4.7

15

72

4

x


* bold letters, part of a network connected by the IPA relationship "Expression" (Fig 3B)

** bold numbers, fc > 1.5, p < 0.005

*** italic number, fc > 1.5, p > 0.005

NC, No change fc < 1.5

**** Expression of the respective gene is known to be regulated by IL1, TNF, IL6, and/or IRF7 (based on Ingenuity Knowledge Database).

G√ľnther et al. BMC Genomics 2012 13:17   doi:10.1186/1471-2164-13-17

Open Data