Table 2

Top ten DEG after short waiting period comparing LPS-primed (P.) versus unstimulated control cells (C.)

Symbol

Entrez Gene Name

Mean ratio

Expression regulated by*

P./C.

IL1

TNF

IL6

IRF7


Priming enhances expression of:

CCL5

chemokine (C-C motif) ligand 5

466

x

x

x

x

SAA3

serum amyloid A3

146

x

FAM14A

family with sequence similarity 14, member A

21

HP

haptoglobin

14

x

x

x

RTP4

receptor (chemosensory) transporter protein 4

13

PARM1

prostate androgen-regulated mucin-like protein 1

8

CFB

complement factor B

7

x

PLAC8

placenta-specific 8

7

HLA-DRA

major histocompatibility complex, class II, DR alpha

6

x

MUC1

mucin 1, cell surface associated

5

x

x

Priming decreases expression of:

ELTD1

EGF, latrophilin and seven transmembrane domain containing 1

-3.5

TRIB3

tribbles homolog 3

-2.1

TBXAS1

thromboxane A synthase 1

-2.0

RASSF4

Ras association domain family 4

-2.0

PYCR1

pyrroline-5-carboxylate reductase 1

-1.9

G0S2

putative lymphocyte G0/G1 switch gene

-1.9

x

x

FUT1

fucosyltransferase 1

-1.8

C1orf24

chromosome 1 open reading frame 24

-1.8

PCTP

phosphatidylcholine transfer protein

-1.6

PSAT1

phosphoserine aminotransferase 1

-1.6


* Expression of the respective gene is known to be regulated by IL1, TNF, IL6, and/or IRF7 (based on Ingenuity Knowledge Database).

G√ľnther et al. BMC Genomics 2012 13:17   doi:10.1186/1471-2164-13-17

Open Data