Figure 3.

ChIP-Seq peaks delineatein vivoPax8 binding site. Image depicts most significant motif defined by the MEME program using the 500 most relevant MACS ChIP-Seq immunoprecipitated peaks and its comparison with Pax proteins-DNA binding consensus sites defined using in vitro approaches (Czerny et al; Pellizzari et al) [13,14] and previously known Pax8 targets, Nis and Tpo respectively (Ohno et al; Zannini et al) [7,9]. Underlined characters highlighted in yellow are nucleotides similar between our Pax8 motif and the other consensus sequences.