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Open Access Research article

Genome-wide host responses against infectious laryngotracheitis virus vaccine infection in chicken embryo lung cells

Jeongyoon Lee12, Walter G Bottje12 and Byung-Whi Kong12*

Author Affiliations

1 Department of Poultry Science, Division of Agriculture, POSC O-404, 1260 West Maple, Fayetteville, AR 72701, USA

2 Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR 72701, USA

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BMC Genomics 2012, 13:143  doi:10.1186/1471-2164-13-143

Published: 24 April 2012

Additional files

Additional file 1:

All 933 differentially expressed genes at four dpi time points of vaccine ILTV infection. The Agilent ID, GenBank accession, gene symbol, log2 fold change (FC), mean log2 FC of four dpi, and their standard deviations (std) are listed.

Format: XLS Size: 139KB Download file

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Additional file 2:

All 213 differentially expressed genes collected by IPA program. The gene expression levels at all time points were determined by log2 fold change. All gene symbols and gene names were generated based on the IPA database and confirmed with the Unigene function of NCBI.

Format: XLS Size: 70KB Download file

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Additional file 3:

GenBank accessions, functions, and major focus molecules in four molecular networks. (A) The top functions of each network, scores and the number of focus molecules are listed in each network. (B) GenBank accession numbers and gene symbols used in network analysis were listed for each network. Focus molecules were bolded and GenBank accession number were provided for focus molecules only. (C) The potentially important focus molecules in each network are listed.

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Additional file 4:

Four gene networks. Symbols of functions for each molecules used to generate molecular networks are displayed. (A) network #1 (B) network #2 (C) network #3 (D) network #4. Enlarged images for each dpi are attached. The green indicates down-regulation, while the red depicts up-regulation. Different color intensities represent levels of log2 fold change in the designated molecule.

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Additional file 5:

The 21 genes showing a similar expression pattern in both virulent strain and vaccine ILTV infection.

Format: DOC Size: 42KB Download file

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