Table 7

List of genes with altered expression according to microarray analysis related to KEGG pathway of protein processing in ER

KEGG

embryo

larvae

name

gene

o.ex.

mut.

o.ex.

mut .

description


NEF

CG10420

down

up

down

up

SIL1, BiP-associated protein, mutated in MSS


Hsp90

hsp83

up

down

down

Heat shock protein 83


PERK

pek

up

down

down

PEK; pancreatic eIF-2alpha kinase, UPR sensor


Hrd1

sip3

up

down

down

septin interacting protein 3, ERAD


DSK2

ubiqn

up

down

down

ubiquilin, ubiquitin-ass./transl. elongation factor EF1B


Cul1

lin19

down

up

up

lin-19-like, ubiquitin protein ligase, cullin homology


Skp1

skpC

down

up

down

skpC, E3 ubiquitin ligase


EDEM

Edem1

up

down

Edem1, Glycoside hydrolase


Ubx

p47

down

down

p47, human NSFL1


Skp1

skpE

down

down

RNA polymerase II transcription elongation factor


Sec23/24

CG1472

down

down

COP complex II, mediator of selective export from ER


UGGT

CG6850

down

UDP-glucose-glycoprotein glucosyltransferase


DOA10

CG1317

down

E3 ubiquitin-protein ligase MARCH6


Sec13/31

CG6773

up

up

up

involved in export from ER, nuclear import, cuticle development


MKK7

CG4353

up

up

hemipterous, Jun kinase kinase


Hsp70

Hspc1

up

Heat shock protein cognate 1


Ubc6/7

CG5823

up

ubiquitin-conjugating enzyme E2 J2


Hsp40

dnajh

up

DnaJ homolog subfamily B member 11


NEF

CG10973

up

hsp70-interacting protein


Bap31

CG13887

up

B-cell receptor-associated protein 31


NEF

CG2918

up

hypoxia up-regulated 1


sHSF

l(2)efl

up

lethal (2) essential for life


IRE-1

ire-1

up

inositol requiring enzyme 1, Ser/Thr kinase, UPR sensor


Hsp70

Hsp68

up

Heat shock protein 68


UbcH5

Ubce2

up

Ubiquitin conjugating enzyme 2


Hsp70

Hspc2

up

Heat shock protein cognate 2


NEF

CG7945

up

BCL2-associated athanogene 2


Sec13/31

CG8266

up

COP II complex, secretory vesicle budding from ER


S2P

S2P

up

endopeptidase


Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. Gene name stands for the particular homologue gene name in Drosophila. Notice that the same KEGG identifier can lead to several different genes. p.res = paternal rescue, mut = mutant, o.ex. = overexpression.

Palgi et al. BMC Genomics 2012 13:134   doi:10.1186/1471-2164-13-134

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