Table 7 |
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|
List of genes with altered expression according to microarray analysis related to KEGG pathway of protein processing in ER |
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|
KEGG |
embryo |
larvae |
||||
|
name |
gene |
o.ex. |
mut. |
o.ex. |
mut . |
description |
|
|
||||||
|
NEF |
CG10420 |
down |
up |
down |
up |
SIL1, BiP-associated protein, mutated in MSS |
|
|
||||||
|
Hsp90 |
hsp83 |
up |
down |
down |
Heat shock protein 83 |
|
|
|
||||||
|
PERK |
pek |
up |
down |
down |
PEK; pancreatic eIF-2alpha kinase, UPR sensor |
|
|
|
||||||
|
Hrd1 |
sip3 |
up |
down |
down |
septin interacting protein 3, ERAD |
|
|
|
||||||
|
DSK2 |
ubiqn |
up |
down |
down |
ubiquilin, ubiquitin-ass./transl. elongation factor EF1B |
|
|
|
||||||
|
Cul1 |
lin19 |
down |
up |
up |
lin-19-like, ubiquitin protein ligase, cullin homology |
|
|
|
||||||
|
Skp1 |
skpC |
down |
up |
down |
skpC, E3 ubiquitin ligase |
|
|
|
||||||
|
EDEM |
Edem1 |
up |
down |
Edem1, Glycoside hydrolase |
||
|
|
||||||
|
Ubx |
p47 |
down |
down |
p47, human NSFL1 |
||
|
|
||||||
|
Skp1 |
skpE |
down |
down |
RNA polymerase II transcription elongation factor |
||
|
|
||||||
|
Sec23/24 |
CG1472 |
down |
down |
COP complex II, mediator of selective export from ER |
||
|
|
||||||
|
UGGT |
CG6850 |
down |
UDP-glucose-glycoprotein glucosyltransferase |
|||
|
|
||||||
|
DOA10 |
CG1317 |
down |
E3 ubiquitin-protein ligase MARCH6 |
|||
|
|
||||||
|
Sec13/31 |
CG6773 |
up |
up |
up |
involved in export from ER, nuclear import, cuticle development |
|
|
|
||||||
|
MKK7 |
CG4353 |
up |
up |
hemipterous, Jun kinase kinase |
||
|
|
||||||
|
Hsp70 |
Hspc1 |
up |
Heat shock protein cognate 1 |
|||
|
|
||||||
|
Ubc6/7 |
CG5823 |
up |
ubiquitin-conjugating enzyme E2 J2 |
|||
|
|
||||||
|
Hsp40 |
dnajh |
up |
DnaJ homolog subfamily B member 11 |
|||
|
|
||||||
|
NEF |
CG10973 |
up |
hsp70-interacting protein |
|||
|
|
||||||
|
Bap31 |
CG13887 |
up |
B-cell receptor-associated protein 31 |
|||
|
|
||||||
|
NEF |
CG2918 |
up |
hypoxia up-regulated 1 |
|||
|
|
||||||
|
sHSF |
l(2)efl |
up |
lethal (2) essential for life |
|||
|
|
||||||
|
IRE-1 |
ire-1 |
up |
inositol requiring enzyme 1, Ser/Thr kinase, UPR sensor |
|||
|
|
||||||
|
Hsp70 |
Hsp68 |
up |
Heat shock protein 68 |
|||
|
|
||||||
|
UbcH5 |
Ubce2 |
up |
Ubiquitin conjugating enzyme 2 |
|||
|
|
||||||
|
Hsp70 |
Hspc2 |
up |
Heat shock protein cognate 2 |
|||
|
|
||||||
|
NEF |
CG7945 |
up |
BCL2-associated athanogene 2 |
|||
|
|
||||||
|
Sec13/31 |
CG8266 |
up |
COP II complex, secretory vesicle budding from ER |
|||
|
|
||||||
|
S2P |
S2P |
up |
endopeptidase |
|||
|
|
||||||
|
Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. Gene name stands for the particular homologue gene name in Drosophila. Notice that the same KEGG identifier can lead to several different genes. p.res = paternal rescue, mut = mutant, o.ex. = overexpression. |
||||||
|
Palgi et al. BMC Genomics 2012 13:134 doi:10.1186/1471-2164-13-134 |
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