Table 4

A brief summary of known/putative functions of the TCSs identified in S. mutans UA159

TCS

Cluster

TCS protein

GenBank

Locus Tag

Functions

References


TCS-1

HK-VicK

RR-VicR

SMU.1516

SMU.1517

Biofilm development, competence development, oxidative stress tolerance, acid tolerance, autolysin production, glucan metabolism, fructan metabolism.

[7,8,10,24,40,42,43]


TCS-2

HK-CiaH

RR-CiaR

SMU.1128

SMU.1129

Sucrose-dependent biofilm formation, competence development, multiple stress response, bacteriocin production

[12,44,45]


TCS-3

HK-CovS

RR-CovR

SMU.1145

SMU.1146

Acid tolerance, hydrogen peroxide resistance, murine macrophage killing.

[12,46]


TCS-4

HK-KinF

RR-LlrF

SMU.928

SMU.927

Acid tolerance, pp(G)pp metabolism, control of alarmone synthesis.

[47,48]


TCS-5

HK- ScnK

RR- ScnR

SMU.1814

SMU.1815

Bacteriocin production*.

[49]*


TCS-6

HK- SpaK

RR- SpaR

SMU.660

SMU.659

Bacteriocin production*, self-protection against anti-microbial peptides*.

[50-52]*


TCS-7

HK- PhoR

RR-YcbL

SMU.1037

SMU.1038

Unknown.


TCS-8

HK-KinG

RR-LlrG

SMU.1009

SMU.1008

Bacteriocin resistance, substrate transport in cell envelope stress.

[53,54]


TCS-9

HK-LevS

RR-LevR

SMU.1965

SMU.1964

Biofilm formation, acid tolerance, fructan metabolism.

[55,56]


TCS-10

HK-LytS

RR-LytT

SMU.577

SMU.576

Biofilm formation, oxidative stress tolerance, autolysis, fructan metabolism, cell wall metabolism*.

[57]*, [48,58]


TCS-11

HK-LiaS

RR-LiaR

SMU.486

SMU.487

Biofilm formation, acid tolerance, cell envelope stress response, bacteriocin production, bacteriocin resistance, sucrose-dependent adherence.

[37,59-62]


TCS-12

HK-HK11

RR-RR11

SMU.1548

SMU.1547

Unknown.


TCS-13

HK-ComD

RR-ComE

SMU.1916

SMU.1917

Biofilm formation, quorum sensing, competence development, bacteriocin production.

[9,44,63-65]


TCS-14

HK

RR

SMU.45

SMU.46

Unknown.


Orhpan RR1

RR-GcrR

SMU.1924

Sucrose-dependent adherence, glucan metabolism, pH homeostasis, competence development.

[66-72]


In case no knowledge is available on the functions of some TCSs in UA159, reports on homologous TCSs in other microorganisms, preferably Streptococcus species (highlighted by the astral sign*) are provided.

Song et al. BMC Genomics 2012 13:128   doi:10.1186/1471-2164-13-128

Open Data