Table 5

The 50 GO terms most expanded in the Mycobacteria relative to the non- Mycobacteria

GO term descriptor

GO term ID

p-valuea

inter-to-intra-centroid difference


c sterol biosynthetic process

GO:0016126

1.00E-10

1.80E+01


b regulation of apoptosis

GO:0042981

1.10E-10

1.90E+01


c 3alpha,7alpha,12alpha-trihydroxy-5beta- cholest-24-enoyl-CoA hydratase activity

GO:0033989

1.40E-10

1.70E+01


c linalool 8-monooxygenase activity

GO:0050056

1.50E-10

1.70E+01


c sterol 14-demethylase activity

GO:0008398

5.10E-09

1.60E+01


c cutinase activity

GO:0050525

5.80E-09

1.60E+01


oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

GO:0016657

1.80E-08

1.40E+01


c diacylglycerol O-acyltransferase activity

GO:0004144

2.10E-08

1.70E+01


ligase activity, forming carbon-carbon bonds

GO:0016885

6.10E-08

1.40E+01


indolylacetylinositol arabinosyltransferase activity

GO:0050409

7.90E-08

1.20E+01


c 4-hydroxy-2-oxovalerate aldolase activity

GO:0008701

1.00E-07

1.10E+01


arylamine N-acetyltransferase activity

GO:0004060

2.80E-07

1.70E+01


c lipid transport

GO:0006869

5.00E-07

1.70E+01


c lipid biosynthetic process

GO:0008610

5.00E-07

8.50E+00


biphenyl-2,3-diol 1,2-dioxygenase activity

GO:0018583

1.40E-06

9.50E+00


cis-stilbene-oxide hydrolase activity

GO:0033961

1.50E-06

1.20E+01


c acyl-[acyl-carrier-protein] desaturase activity

GO:0045300

1.70E-06

1.00E+01


5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrog activity

GO:0018480

2.00E-06

1.20E+01


c fatty-acyl-CoA synthase activity

GO:0004321

2.10E-06

1.20E+01


c steroid biosynthetic process

GO:0006694

2.30E-06

1.20E+01


c propanoyl-CoA C-acyltransferase activity

GO:0033814

2.50E-06

1.20E+01


extracellular matrix binding

GO:0050840

2.70E-06

1.30E+01


lipid glycosylation

GO:0030259

6.70E-06

5.60E+00


d coenzyme F420-dependent N5, N10-methenyltetrahydromethanopterinreductase activity

GO:0018537

6.90E-06

1.20E+01


C-terminal protein amino acid methylation

GO:0006481

1.10E-05

1.10E+01


metabolic process

GO:0008152

1.30E-05

4.60E+00


4-oxalocrotonate decarboxylase activity

GO:0047437

1.70E-05

1.10E+01


oxidoreductase activity

GO:0016491

1.80E-05

5.20E+00


oxidation reduction

GO:0055114

1.90E-05

4.80E+00


defense response to bacterium

GO:0042742

2.40E-05

1.60E+01


b cyclopropane-fatty-acyl-phospholipid synthase activity

GO:0008825

2.90E-05

9.80E+00


c 3-hydroxy-2-methylbutyryl-CoA dehyd. activity

GO:0047015

3.40E-05

1.10E+01


nutrient reservoir activity

GO:0045735

3.40E-05

9.30E+00


structural constituent of cell wall

GO:0005199

3.60E-05

7.90E+00


2-nitropropane dioxygenase activity

GO:0018580

4.10E-05

1.40E+01


adenylate cyclase activity

GO:0004016

6.00E-05

9.50E+00


b beta-lactam antibiotic catabolic process

GO:0030655

6.70E-05

1.40E+01


DNA primase activity

GO:0003896

8.40E-05

1.10E+01


cyclic nucleotide biosynthetic process

GO:0009190

8.50E-05

9.80E+00


iron ion transport

GO:0006826

8.70E-05

1.20E+01


di-, tri-valent inorganic cation transmembrane transporter activity

GO:0015082

9.00E-05

6.80E+00


phosphorus-oxygen lyase activity

GO:0016849

1.60E-04

9.50E+00


limonene-1,2-epoxide hydrolase activity

GO:0018744

1.60E-04

7.80E+00


c fatty acid metabolic process

GO:0006631

1.70E-04

8.40E+00


sirohydrochlorin cobaltochelatase activity

GO:0016852

1.80E-04

1.50E+01


intracellular signaling cascade

GO:0007242

2.00E-04

8.80E+00


c enoyl-CoA hydratase activity

GO:0004300

2.30E-04

1.30E+01


di-, tri-valent inorganic cation transport

GO:0015674

2.40E-04

6.20E+00


c acyl-CoA dehydrogenase activity

GO:0003995

2.60E-04

9.10E+00


catechol O-methyltransferase activity

GO:0016206

3.20E-04

1.50E+01


aBonferroni-corrected p-value calculated from T-test

b pathogenicity or survival within the host

c Lipid metabolism

d Cofactor biosynthesis

e unknown function

McGuire et al. BMC Genomics 2012 13:120   doi:10.1186/1471-2164-13-120

Open Data