Table 3 |
|||
|
The 50 GO terms most expanded in the Mtb clade relative to the non-pathogenic, soil-dwelling Mycobacteria |
|||
|
GO descriptor |
GO term ID |
p-valuea |
inter-to-intra centroid difference |
|
|
|||
|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate red. activity |
GO_0051745 |
4.80E-08 |
7.20E+00 |
|
|
|||
|
dTMP biosynthetic process |
GO_0006231 |
7.30E-07 |
4.40E+00 |
|
|
|||
|
response to cAMP |
GO_0051591 |
1.40E-06 |
1.20E+01 |
|
|
|||
|
succinate dehydrogenase (ubiquinone) activity |
GO_0008177 |
1.70E-06 |
5.10E+00 |
|
|
|||
|
iron ion transport |
GO_0006826 |
2.70E-06 |
4.70E+00 |
|
|
|||
|
magnesium ion binding |
GO_0000287 |
2.80E-06 |
1.70E+00 |
|
|
|||
|
c fatty-acyl-CoA synthase activity |
GO_0004321 |
5.10E-06 |
6.50E+00 |
|
|
|||
|
c acyltransferase activity |
GO_0008415 |
7.60E-06 |
3.60E+00 |
|
|
|||
|
transferase activity, transferring alkyl or aryl (other than methyl) groups |
GO_0016765 |
1.30E-05 |
2.60E+00 |
|
|
|||
|
c tricarboxylic acid cycle |
GO_0006099 |
1.30E-05 |
3.40E+00 |
|
|
|||
|
d Mo-molybdopterin cofactor biosynthetic process |
GO_0006777 |
1.40E-05 |
6.30E+00 |
|
|
|||
|
integral to membrane |
GO_0016021 |
2.00E-05 |
2.00E+00 |
|
|
|||
|
acid phosphatase activity |
GO_0003993 |
2.50E-05 |
3.20E+00 |
|
|
|||
|
phosphatase activity |
GO_0016791 |
3.20E-05 |
4.10E+00 |
|
|
|||
|
erythronolide synthase activity |
GO_0047879 |
4.20E-05 |
8.20E+00 |
|
|
|||
|
d 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
GO_0008124 |
6.80E-05 |
6.20E+00 |
|
|
|||
|
c lipid metabolic process |
GO_0006629 |
6.80E-05 |
4.70E+00 |
|
|
|||
|
bacteriochlorophyll biosynthetic process |
GO_0030494 |
7.00E-05 |
1.30E+00 |
|
|
|||
|
plasma membrane |
GO_0005886 |
7.10E-05 |
2.70E+00 |
|
|
|||
|
d tetrahydrobiopterin biosynthetic process |
GO_0006729 |
1.10E-04 |
8.80E+00 |
|
|
|||
|
c lipid biosynthetic process |
GO_0008610 |
1.20E-04 |
3.50E+00 |
|
|
|||
|
phosphatidylcholine metabolic process |
GO_0046470 |
1.60E-04 |
9.50E+00 |
|
|
|||
|
c geranyltranstransferase activity |
GO_0004337 |
1.60E-04 |
6.80E+00 |
|
|
|||
|
cytoplasm |
GO_0005737 |
1.90E-04 |
1.40E+00 |
|
|
|||
|
protein transport |
GO_0015031 |
1.90E-04 |
1.70E+00 |
|
|
|||
|
guanosine tetraphosphate metabolic process |
GO_0015969 |
2.20E-04 |
5.00E+00 |
|
|
|||
|
glyoxylate cycle |
GO_0006097 |
2.20E-04 |
4.30E+00 |
|
|
|||
|
phosphoglycolate phosphatase activity |
GO_0008967 |
2.80E-04 |
4.30E+00 |
|
|
|||
|
terpenoid biosynthetic process |
GO_0016114 |
3.90E-04 |
2.80E+00 |
|
|
|||
|
sulfur metabolic process |
GO_0006790 |
4.10E-04 |
5.30E+00 |
|
|
|||
|
4 iron, 4 sulfur cluster binding |
GO_0051539 |
5.00E-04 |
2.90E+00 |
|
|
|||
|
succinate dehydrogenase activity |
GO_0000104 |
5.70E-04 |
4.60E+00 |
|
|
|||
|
b mycocerosate synthase activity |
GO_0050111 |
5.80E-04 |
4.10E+00 |
|
|
|||
|
c phospholipid biosynthetic process |
GO_0008654 |
6.10E-04 |
2.30E+00 |
|
|
|||
|
nucleoside metabolic process |
GO_0009116 |
6.30E-04 |
3.60E+00 |
|
|
|||
|
c phosphopantetheine binding |
GO_0031177 |
8.20E-04 |
3.00E+00 |
|
|
|||
|
adenylate cyclase activity |
GO_0004016 |
8.30E-04 |
5.50E+00 |
|
|
|||
|
D-arabinono-1,4-lactone oxidase activity |
GO_0003885 |
9.70E-04 |
8.40E+00 |
|
|
|||
|
anaerobic respiration |
GO_0009061 |
9.90E-04 |
1.10E+01 |
|
|
|||
|
nodulation |
GO_0009877 |
1.10E-03 |
7.10E+00 |
|
|
|||
|
c prenyltransferase activity |
GO_0004659 |
1.10E-03 |
4.20E+00 |
|
|
|||
|
c lysophospholipase activity |
GO_0004622 |
1.30E-03 |
8.50E+00 |
|
|
|||
|
c acetyl-CoA carboxylase activity |
GO_0003989 |
1.30E-03 |
2.40E+00 |
|
|
|||
|
histidinol-phosphatase activity |
GO_0004401 |
2.10E-03 |
6.50E+00 |
|
|
|||
|
pyridine nucleotide biosynthetic process |
GO_0019363 |
2.30E-03 |
5.00E+00 |
|
|
|||
|
NAD biosynthetic process |
GO_0009435 |
3.30E-03 |
1.30E+00 |
|
|
|||
|
lactate fermentation to propionate and acetate |
GO_0019652 |
3.40E-03 |
3.40E+00 |
|
|
|||
|
alkylglycerone-phosphate synthase activity |
GO_0008609 |
3.40E-03 |
7.10E+00 |
|
|
|||
|
b cyclopropane-fatty-acyl-phospholipid synthase activity |
GO_0008825 |
4.00E-03 |
5.90E+00 |
|
|
|||
|
methylcrotonoyl-CoA carboxylase activity |
GO_0004485 |
4.40E-03 |
3.00E+00 |
|
|
|||
|
aBonferroni-corrected p-value calculated from T-test b pathogenicity or survival within the host c Lipid metabolism d Cofactor biosynthesis e unknown function |
|||
|
McGuire et al. BMC Genomics 2012 13:120 doi:10.1186/1471-2164-13-120 |
|||
