Open Access Highly Accessed Research article

Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

Abigail Manson McGuire19*, Brian Weiner1, Sang Tae Park4, Ilan Wapinski18, Sahadevan Raman4, Gregory Dolganov6, Matthew Peterson3, Robert Riley2, Jeremy Zucker1, Thomas Abeel15, Jared White1, Peter Sisk1, Christian Stolte1, Mike Koehrsen1, Robert T Yamamoto7, Milena Iacobelli-Martinez7, Matthew J Kidd7, Andreia M Maer7, Gary K Schoolnik6, Aviv Regev1 and James Galagan134

Author Affiliations

1 Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA

2 DOE Joint Genome Institute, Walnut Creek, CA, USA

3 Department of Biomedical Engineering, Boston University, Boston, MA, USA

4 Departments of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA

5 VIB Department of Plant Systems Biology, Ghent University, Technologiepark 927, 9052 Ghent, Belgium

6 Stanford University, Palo Alto, CA, USA

7 FLIR, Chem-Bio Detection, 505 Coast Boulevard South, Suite 309, La Jolla, CA 92037, USA

8 Department of Systems Biology, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115, USA

9 The Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA

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BMC Genomics 2012, 13:120  doi:10.1186/1471-2164-13-120

Published: 28 March 2012

Additional files

Additional file 1:

Supplementary Results [110-130].

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Additional file 2:

Additional related tetR family regulators (2-3 copies in each environmental Mycobacterium).

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Additional file 3:

Northern Blots for small RNAs in M. tuberculosis.

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Additional file 4:

Genomes contained in orthogroups.

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Additional file 5:

Phylogenetic tree showing bootstrap results.

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