Table 1

Gene Ontology (GO) analysis of placenta-enriched genes

Tissue

Category#

Term

Number of genes

P-Value

Fold Enrichment

Bonferroni-corrected P-Value


Amnion

GO_BP

GO:0007398 ~ ectoderm development

46

9.95E-21

5.3

2.51E-17


Amnion

GO_BP

GO:0008544 ~ epidermis development

43

1.28E-19

5.4

3.23E-16


Amnion

GO_BP

GO:0007155 ~ cell adhesion

76

1.71E-12

2.4

4.31E-09


Amnion

GO_BP

GO:0022610 ~ biological adhesion

76

1.85E-12

2.4

4.67E-09


Amnion

GO_BP

GO:0030855 ~ epithelial cell differentiation

27

1.46E-10

4.5

3.68E-07


Amnion

GO_BP

GO:0009913 ~ epidermal cell differentiation

19

2.80E-10

6.5

7.07E-07


Amnion

GO_BP

GO:0030216 ~ keratinocyte differentiation

18

4.05E-10

6.8

1.02E-06


Amnion

GO_BP

GO:0060429 ~ epithelium development

33

7.05E-09

3.2

1.78E-05


Amnion

GO_BP

GO:0018149 ~ peptide cross-linking

10

1.14E-06

8.5

2.87E-03


Amnion

GO_BP

GO:0031424 ~ keratinization

10

1.53E-05

6.4

3.79E-02


Amnion

GO_BP

GO:0043062 ~ extracellular structure organization

22

1.86E-05

2.9

4.59E-02


Amnion

GO_BP

GO:0030198 ~ extracellular matrix organization

17

1.91E-05

3.6

4.69E-02


Amnion

KEGG

hsa04512:ECM-receptor interaction

21

5.92E-10

5.4

8.05E-08


Amnion

KEGG

hsa04510:Focal adhesion

28

2.30E-07

3.1

3.13E-05


Chorion

GO_BP

GO:0007155 ~ cell adhesion

73

1.33E-11

2.3

3.43E-08


Chorion

GO_BP

GO:0022610 ~ biological adhesion

73

1.46E-11

2.3

3.77E-08


Chorion

GO_BP

GO:0007166 ~ cell surface receptor linked signal transduction

123

1.09E-09

1.7

2.81E-06


Chorion

GO_BP

GO:0007398 ~ ectoderm development

30

4.77E-09

3.6

1.23E-05


Chorion

GO_BP

GO:0007223 ~ Wnt receptor signaling pathway, calcium modulating pathway

11

9.29E-09

11.3

2.40E-05


Chorion

GO_BP

GO:0008544 ~ epidermis development

28

1.35E-08

3.6

3.49E-05


Chorion

GO_BP

GO:0007565 ~ female pregnancy

21

9.50E-08

4.2

2.46E-04


Chorion

GO_BP

GO:0009611 ~ response to wounding

51

3.61E-07

2.2

9.33E-04


Chorion

GO_BP

GO:0051270 ~ regulation of cell motion

27

7.39E-07

3.0

1.91E-03


Chorion

GO_BP

GO:0001501 ~ skeletal system development

36

1.72E-06

2.4

4.43E-03


Chorion

GO_BP

GO:0060429 ~ epithelium development

28

2.25E-06

2.8

5.79E-03


Chorion

GO_BP

GO:0001568 ~ blood vessel development

30

2.29E-06

2.7

5.91E-03


Chorion

GO_BP

GO:0030334 ~ regulation of cell migration

24

2.62E-06

3.1

6.76E-03


Chorion

GO_BP

GO:0016055 ~ Wnt receptor signaling pathway

21

3.00E-06

3.4

7.73E-03


Chorion

GO_BP

GO:0001944 ~ vasculature development

30

3.75E-06

2.6

9.65E-03


Chorion

GO_BP

GO:0042127 ~ regulation of cell proliferation

64

6.58E-06

1.8

1.69E-02


Chorion

GO_BP

GO:0035295 ~ tube development

27

7.56E-06

2.7

1.94E-02


Chorion

GO_BP

GO:0048514 ~ blood vessel morphogenesis

26

1.06E-05

2.7

2.71E-02


Chorion

GO_BP

GO:0001525 ~ angiogenesis

21

1.14E-05

3.1

2.92E-02


Chorion

KEGG

hsa04060:Cytokine-cytokine receptor interaction

38

3.89E-10

3.1

5.48E-08


Chorion

KEGG

hsa04512:ECM-receptor interaction

19

7.54E-08

4.6

1.06E-05


Chorion

KEGG

hsa04340:Hedgehog signaling pathway

14

1.99E-06

5.1

2.80E-04


Chorion

KEGG

hsa05217:Basal cell carcinoma

13

9.93E-06

4.8

1.40E-03


Chorion

KEGG

hsa04510:Focal adhesion

25

2.91E-05

2.6

4.09E-03


Chorion

KEGG

hsa05200:Pathways in cancer

33

9.39E-05

2.1

1.32E-02


Chorion

PANTHER

P00034:Integrin signalling pathway

26

5.49E-04

2.0

4.40E-02


Decidua

GO_BP

GO:0007565 ~ female pregnancy

27

4.48E-12

5.2

1.20E-08


Decidua

GO_BP

GO:0042060 ~ wound healing

26

2.91E-06

2.9

7.77E-03


Decidua

GO_BP

GO:0048732 ~ gland development

20

1.55E-05

3.2

4.08E-02


Analysis was performed on genes identified as being enriched in each of the three placental tissues compared to the other 16 human tissues

# GO term Biological Process categories are based on GO FAT definition from the DAVID website; KEGG and PANTHER are the corresponding pathways defined in the DAVID website.

Kim et al. BMC Genomics 2012 13:115   doi:10.1186/1471-2164-13-115

Open Data