Analysis of enriched GO groups in genes showing significant altered expression in the different experimental conditions by GO domains. A) GO Cellular component, B) GO Biological process &C) GO Molecular function. We have use the symbols +/- when the list of genes used as input for the BINGO GO tool were filtered using limma p value and ↑/↓ when the lists were filtered using the FDR-rankprod p value, analyzing up- (+/↑) and down-regulated (-/↓) gene lists separately. The following GO groups are significantly overrepresented in each sample as determined using BINGO 2.3 with default settings (one symbol indicate a p < 0.001 and two symbols a p < 0.0005 using a hypergeometric test with BH-FDR algorithm). We use shading to indicate if this GO term is overrepresented using limma p value input list (soft shaded) only, both lists (dark shaded) or FDR rankprod p value list only (black shaded, white letters).
Manzano et al. BMC Genomics 2012 13:105 doi:10.1186/1471-2164-13-105