A graph showing the proteins associated with PF10_0111. This protease is the most highly connected member of the set of proteases found in the P. falciparum ubiquitin-proteasome protein degradation system. Square nodes represent proteases. Node size is proportional to the degree of the node. Nodes are colored according to their functional classification in the eggNOG database . The COG categories are  (J) Translation, ribosomal structure and biogenesis, (A) RNA processing and modification, (K) Transcription, (L) Replication, recombination and repair, (B) Chromatin structure and dynamics, (D) Cell cycle control, cell division, chromosome partitioning, (Y) Nuclear structure, (V) Defense mechanisms, (T) Signal transduction mechanisms, (M) Cell wall/membrane/envelope biogenesis, (N) Cell motility, (Z) Cytoskeleton, (W) Extracellular structures, (U) Intracellular trafficking, secretion, and vesicular transport, (O) Posttranslational modification, protein turnover, chaperones, (C) Energy production and conversion, (G) Carbohydrate transport and metabolism, (E) Amino acid transport and metabolism, (F) Nucleotide transport and metabolism, (H) Coenzyme transport and metabolism, (I) Lipid transport and metabolism, (P) Inorganic ion transport and metabolism, (Q) Secondary metabolites biosynthesis, transport and catabolism, (R) General function prediction only, and (S) Function unknown. Confidence scores for the interactions among the nodes (S values from STRING) were divided into three groups - low (0.150-0.399), medium (0.400-0.700) and high (0.701-0.999); the groups are represented by thin, medium and heavy lines, respectively.
Lilburn et al. BMC Genomics 2011 12(Suppl 5):S9 doi:10.1186/1471-2164-12-S5-S9