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This article is part of the supplement: The 2010 International Conference on Bioinformatics and Computational Biology (BIOCOMP 2010): Genomics

Open Access Highly Accessed Research article

Protease-associated cellular networks in malaria parasite Plasmodium falciparum

Timothy G Lilburn1, Hong Cai2, Zhan Zhou23 and Yufeng Wang24*

Author Affiliations

1 Department of Bacteriology, American Type Culture Collection, Manassas, VA 20110, USA

2 Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA

3 College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China

4 South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249, USA

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BMC Genomics 2011, 12(Suppl 5):S9  doi:10.1186/1471-2164-12-S5-S9

Published: 23 December 2011

Additional files

Additional file 1:

P. falciparum proteases and their degrees of connectivity in protein association networks.

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Additional file 2:

The protein-protein associations involving proteases in Plasmodium falciparum.

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Additional file 3:

Functional categories involving protease associations identified by Gene Ontology enrichment analysis.

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Additional file 4:

The graph shows the set of proteins associated with the proteases thought to be part of the P. falciparum ubiquitin-proteasome protein degradation system. Nodes are colored according to their functional classification in the eggNOG database [122] (key is shown). Node size is proportional to the degree of the node. Confidence scores for the interactions among the nodes (S values from STRING) were divided into three groups - low (0.150-0.399), medium (0.400-0.700) and high (0.701-0.999); the groups are represented by thin, medium and heavy lines, respectively.

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