Table 1

Spearman's rank correlation coefficients (ρs) and partial correlations between gene's promoter methylation level and the number of microRNA target sites

Number of microRNA target sites by mirTarget2 (Nt)

Number of microRNA target sites by PicTar (Np)

3' UTR length (UL)




Promoter methylation level (m)

Correlation ρs (m, Nt)

Partial correlation ρs (m,Nt|gene expression level)

Correlation ρs (m, Np)

Partial correlation ρs (m,Np|gene expression level)

Correlation ρs (m, UL)

Partial correlation ρs (m,UL|gene expression level)




Promoter mCG/CG

(H1)

-0.29***

-0.19***

-0.29***

-0.22***

-0.31***

-0.22***

Promoter mCG/CG (IMR90)

-0.26***

-0.19***

-0.28***

-0.19***

-0.29***

-0.20***

Promoter CpGO/E

0.29***

0.16 ***

0.28***

0.18 ***

0.31***

0.19 ***


A germline tissue (FETAL.OVARY.14.4WK) having the most significant correlation between expression level and promoter region CpGO/E ratio was selected [30].*** P < 10-15.

Su et al. BMC Genomics 2011 12(Suppl 5):S15   doi:10.1186/1471-2164-12-S5-S15

Open Data