Format of ADR vs. drug target facts and an example of drug target expanding network. a) This figure shows the format of ADR vs. drug target facts. Dn, Si, and Tj mean drug n, ADR i, and target j respectively. b) This figure is an example of a drug target expanding network. The dotted lines mean PPIs. c) This part illustrates the process of the drug target expanding one level in PPI network. T1, T2, and T5 are present twice in all branches of this expanding "tree", thus the values in cells DT11, DT12, and DT15 in ADR vs. drug target facts are all 2; the rest, including DT13 and DT14, are both 1.
Huang et al. BMC Genomics 2011 12(Suppl 5):S11 doi:10.1186/1471-2164-12-S5-S11