Cardiotoxicity-associated PPI network. The 101 proteins that passed the feature selection in the "2 Stars UP" PPI network are used to establish a cardiotoxicity-associated PPI network. We use light blue, deep blue, light red, and deep red lines to represent 2 to 5 stars PPIs respectively. A node with a green and thick border means a drug target which is docked by a drug reported to have cardiotoxicity-associated ADRs. Node color illustrates the paper number we obtained from PubMed by searching the protein name and the term of "Heart Disease" together. The diamond shape on the top right site of a node shows the paper number we obtained from PubMed by searching the protein name and the term of "Cardiotoxicity" together.
Huang et al. BMC Genomics 2011 12(Suppl 5):S11 doi:10.1186/1471-2164-12-S5-S11