Table 3

Characteristics of signal peptidases and target signal peptides

Model Signal Peptidase

Example Protein

Merops Family & domains

Translocation system

Signal peptide domain

Example substrates

Domains

Comments


N-terminal Processing


PilD PulO GspO

SO_0414

A24A

T2aSS

pfam07963

GspGHIJK

pfam02501 pfam03934 pfam08334 pfam12019

Signal peptides similar, except ones in IVb pili are longer (~25 aa) than others (~7 aa), GspK, PilX, PilW are not detected by pfam07963



T2bSS

type IVa pili


type IVb pili


TadV

Spea_2010

A24A

T2cSS

Flp, TadEF


LspA

SO_3531

A08

pfam01252

Sec

Lipo-proteins



Tat

TIGR01409 pfam10518


NA1

SO_A0049

C39

T1SS

TIGR01847

class Ia & IIa-b bacteriocin, microcins

pfam01721 pfam10439 pfam10439

The signal peptidase activity is encoded in the permease component of the T1SS system that exports the bacteriocin


LepB

SO_1347

S26A

pfam00717

Sec

exported proteins



Tat

TIGR01409 pfam10518


C-terminal processing


?

T4bSS - IncF

TraA

mature TraA is about ~68 aa in length with two TM spans that circularizes


TrhF

Shewana3_4209

S26A

T4bSS - IncH

TrhA HdtZ

Substrates have Sec signal peptide that is cleaved by LepB


TraF

Sputw3181_1142

S26A

T4bSS - IncJ

TraA

TIGR02758


TraF

Shewana3_1267

S26C

pfam00717

T4bSS - IncP

TrbC

pfam04956


Romine BMC Genomics 2011 12(Suppl 1):S1   doi:10.1186/1471-2164-12-S1-S1

Open Data