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This article is part of the supplement: Validation methods for functional genome annotation

Open Access Introduction

Introduction: Validation methods for function genome annotation

Marvin Stodolsky

Author Affiliations

Retired from the US Department of Energy, DOE Office of Biological and Environmental Research, 1991-2010

BMC Genomics 2011, 12(Suppl 1):I1  doi:10.1186/1471-2164-12-S1-I1

Published: 15 June 2011

First paragraph (this article has no abstract)

This supplement comprises a report on progress during 2007-10 on an outstanding and continuing problem. What are effective and high throughput methodologies for validating the function of genes, newly displayed within DNA sequences? The display of genomes as DNA sequence is becoming increasingly cheap and fast. Sequence comparison methodologies do serve for computationally recognizing homologues between genes in a newly displayed genome, with those of previously analyzed genomes. This is a first automated step in annotation of newly recognized, candidate genes. But there are abundant examples that follow through experimentation is needed to improve and often also to correct the first outputs of computational annotation. For newly displayed microbial genomes, about a third of the genes do not thus acquire any functional assignment. For the more complex genomes of higher species, gene coverage by automated annotation is even poorer.