Table 4

Differences (p-value) in diabetes related traits in the 8 confirmed bimodal genes for those in the high compared with those in the low RNA expression mode.

Gene

Δ BMIa

Δ %fata

Δ log10(Mlow)b

Δ AIRc


GSTM1

-0.408 (p = 0.67)

-0.88 (p = 0.28)

0.015 (p = 0.46)

-1.73 (p = 0.96)


HLA-DRB1

2.04 (p = 0.09)

1.15 (p = 0.32)

-0.0033 (p = 0.89)

31.6 (p = 0.49)


ERAP2

-0.122 (p = 0.9)

0.472 (p = 0.58)

-0.0033 (p = 0.86)

54.4 (p = 0.11)


HLA-DRB5

2.19 (p = 0.072)

1.22 (p = 0.29)

-0.0095 (p = 0.69)

31.6 (p = 0.49)


MAOA

0.949 (p = 0.29)

1.78 (p = 0.018)

-0.0001 (p = 1.0)

-44.1 (p = 0.17)


ACTN3

0.71 (p = 0.46)

0.284 (p = 0.72)

-0.050 (p = 0.0076)

53.5 (p = 0.14)


NR4A2

-0.576 (p = 0.57)

-0.836 (p = 0.36)

-0.010 (p = 0.63)

-2.05 (p = 0.96)


THNSL2

0.695 (p = 0.47)

0.671 (p = 0.48)

0.0062 (p = 0.81)

2.23 (p = 0.97)


The number of individuals measured for each phenotype varied (n).

a adjusted for age, gender, sibship, and heritage; BMI = body mass index (n = 225), %fat = percent body fat (n = 223)

b adjusted for age, gender, sibship, heritage, and % body fat; Mlow = insulin sensitivity (n = 182)

c adjusted for age, gender, sibship, heritage, % body fat, and Mlow; AIR = acute insulin response (n = 79 normal glucose tolerant individuals with full heritage and covariates)

Mason et al. BMC Genomics 2011 12:98   doi:10.1186/1471-2164-12-98

Open Data