Open Access Highly Accessed Research article

Bimodal distribution of RNA expression levels in human skeletal muscle tissue

Clinton C Mason*, Robert L Hanson, Vicky Ossowski, Li Bian, Leslie J Baier, Jonathan Krakoff and Clifton Bogardus

Author Affiliations

From the Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E. Indian School Rd., Phoenix, AZ, 85014, USA

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BMC Genomics 2011, 12:98  doi:10.1186/1471-2164-12-98

Published: 7 February 2011

Additional files

Additional file 1:

Figure illustrating how dichotomous gene level RNA expression can be artifact of batch effect.

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Additional file 2:

Summary of 16 genes (associated with gender) which met all criteria for bimodality in either group A or group B.

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Additional file 3:

Summary of bimodal genes found on trimmed bimodal data sets of non-gender associated genes. Listed are 28 genes which had a false discovery rate on the Fisher combined p-value from the two trimmed data sets <1.0. Fourteen of these have an FDR < 0.05.

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Additional file 4:

Summary of bimodal genes found on trimmed bimodal data sets of gender associated (p < 0.05) genes. Listed are 30 genes which had a false discovery rate on the Fisher combined p-value from the two trimmed data sets <1.0. Twelve of these have an FDR < 0.05.

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Additional file 5:

List of 211 SNPs associated with component of muscle expression with p < 7 × 10-8 in the 32 bimodally expressed genes.

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Additional file 6:

Comparison of bimodal gene sets found in the various populations analyzed.

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