Table 3

Differential expression between the Lean and Fat mice in liver genes

Gene name

Gene Symbol

GeneBank Code

Log2 ratio*

L:F**


Cholesterol metabolism

Mevalonate kinase

Mvk

NM_023556

0.11

NAD(P) dependent steroid dehydrogenase-like

Nsdhl

BC019945

0.15

Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)

Sc5d

BC024132

0.27

Mevalonate (diphospho) decarboxylase

Mvd

NM_138656

0.29

Lanosterol synthase

Lss

NM_146006

0.33

Farnesyl diphosphate synthetase

Fdps

NM_134469

0.41

Farnesyl diphosphate farnesyl transferase 1

Fdft1

NM_010191

0.44

Acyl-CoA synthetase short-chain family member 2

Acss2

NM_019811

0.36

Bile acid and glucose metabolism

Glucose-6-phosphatase, catalytic

G6Pc

NM_008061

-1.01

Pyruvate dehydrogenase (lipoamide) beta

Pdhb

NM_024221

-0.28

Solute carrier organic anion transporter family, member 1a4

Slco1a4

NM_030687

-0.71

Solute carrier organic anion transporter family, member 1a1

Slco1a1

AY195868

-0.49

Solute carrier organic anion transporter family, member 1b2

Slco1b2

NM_020495

-0.36

Solute carrier family 10 (sodium/bile acid cotransporter family), member 1

Slc10a1

BC094023

-0.13

ATP-binding cassette, sub-family G (WHITE), member 5

Abcg5

NM_031884

-0.15

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Abcb11

NM_021022

0.65

Cytochrome P450, family 8, subfamily b, polypeptide 1

Cyp8b1

NM_010012

0.52

Drug metabolism

Cytochrome P450, family 2, subfamily a, polypeptide 5

Cyp2a5

BC011233

-0.52

Cytochrome P450, family 2, subfamily b, polypeptide 10

Cyp2b10

AK028103

-0.44

Cytochrome P450, family 2, subfamily b, polypeptide 9

Cyp2b9

NM_010000

-0.38

Cytochrome P450, family 2, subfamily b, polypeptide 9

Cyp2b9

NM_007813

-0.38

Cytochrome P450, family 3, subfamily a, polypeptide 41A

Cyp3a41a

NM_017396

-0.37

Cytochrome P450, family 2, subfamily c, polypeptide 69

Cyp2c69

NM_010004

0.34

Cytochrome P450, family 1, subfamily a, polypeptide 2

Cyp1a2

NM_009993

0.41

Others

Complement component 9

C9

BC011137

-1.37

Serum amyloid P-component

Apcs

BC061125

0.46

Complement component 4B (Childo blood group)

C4b

BC067409

1.55

C-reactive protein, pentraxin-related

Crp

NM_007768

0.25

Orosomucoid 1

Orm1

BC012725

-0.34

Hemopexin

Hpxn

BC019901

0.12

Nuclear receptor subfamily 5, group A, member 2 (LRH-1)

Nr5a2

NM_030676

0.16

Acetyl-Coenzyme A acetyltransferase 2

Acat2

NM_009338

0.22

Apolipoprotein A-II

Apoa2

BC031786

0.23

Lysosomal acid lipase A

Lip1

NM_021460

0.23

Low density lipoprotein receptor

Ldlr

BC019207

0.27

Insulin induced gene 1

Insig1

NM_153526

0.33

Nitric oxide synthase 1, neuronal

Nos1

BC066101

0.34

Adiponectin receptor 2

Adipor2

NM_197985

0.35


*Data represent log2 ratios of Lean (L) versus Fat (F) line (p < 0.05).

**Up arrow indicates increased mRNA expression of particular gene in the Lean (L) line and down arrow decreased expression in the Lean line.

Simončič et al. BMC Genomics 2011 12:96   doi:10.1186/1471-2164-12-96

Open Data