Analysis of the upc2 deletion in C. parapsilosis. (A) Wildtype and upc2 deletion strains of C. albicans and C. parapsilosis were grown on YPD or YPD + 0.02 mg/ml ketoconazole plates for 5 days. Deleting UPC2 greatly increases the sensitivity of both species to ketoconazole. Strains: C. albicans WT (SC5314), C. albicans upc2Δ (TW14920), C. parapsilosis WT (CLIB214), and two independent knockouts of upc2in C. parapsilosis (CDupc5 and CDupc7). (B) Cluster analysis of genes differentially expressed in hypoxia and in the upc2 deletion of C. parapsilosis. Details of the clusters are provided in Additional file 15. (C) Clusters 2, 3 and 4 from (B). The names of the C. albicans orthologs are given where available. Where there is no ortholog, the cpar2 gene name is shown.
Guida et al. BMC Genomics 2011 12:628 doi:10.1186/1471-2164-12-628