Open Access Research article

Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes

Kate E Killick1, John A Browne1, Stephen DE Park1, David A Magee1, Irene Martin1, Kieran G Meade2, Stephen V Gordon1,3, Eamonn Gormley4, Cliona O'Farrelly5, Karsten Hokamp6 and David E MacHugh1,3*

1 UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland

2 Animal Bioscience Centre, Teagasc, Grange, Dunsany, County Meath, Ireland

3 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland

4 Tuberculosis Diagnostics and Immunology Research Centre, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland

5 Comparative Immunology Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

6 Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland

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BMC Genomics 2011, 12:611 doi:10.1186/1471-2164-12-611

Published: 19 December 2011

Additional files

Additional file 1:

Perl script used for bootstrapping of cluster analysis results in Figure 2.

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Additional file 2:

Table S1: Oligonucleotide primers used for real time qRT-PCR validation of microarray results.

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