Additional file 3.

Table S3 Genes with known functions in Treg cells. The table lists genes that have been described in the literature to exhibit a functional role in Treg cells. Table S4: Treg functional genes with a higher expression in Tregs. The table lists probesets of genes that were expressed at a higher level in Treg compared to Th cells and which exhibit known Treg functions. Table S5. Genes regulated by cis-eQTL in Treg cells. The table lists probesets from genes that exhibited a cis-eQTL larger or equal to an LRS of 18 in Treg but not in Th cells and which were expressed at least 2-fold higher in Treg cells. Table S6. Genes regulated by cis-eQTL (LRS > = 18) in Th. The table lists probesets from genes that exhibited a cis-eQTL larger or equal to an LRS of 18 in Th but not in Treg cells and which were expressed at least 2-fold higher in Th cells. Table S7. Treg specific genes regulated by trans-eQTL in Treg cells. The table lists probesets from genes that exhibited a trans-eQTL larger or equal to an LRS of 18 in Treg but not in Th cells and which were expressed at least 2-fold higher in Treg cells. Table S8. Th specific genes regulated by trans-eQTL in Th cells. The table lists probesets from genes that exhibited a trans-eQTL larger or equal to an LRS of 18 in Th but not in Treg cells and which were expressed at least 2-fold higher in Th cells. Table S9. Treg functional genes regulated and highly expressed in Treg cells. The table lists probesets of differentially expressed genes in Treg cells with a known Treg function, a high expression signal in Tregs (expression signal > 8) and which are regulated by a trans-eQTL with an LRS > = 14. Table S10: Intervals selected for further QTL analysis. The table lists the QTL intervals from selected Treg and Th cis- and trans-eQTLs that were further analyzed for the presence of candidate regulatory genes. Table S11 Candidate genes located in the F2rl1-QTL interval on chromosome 4. The table lists probesets of possible candidate genes that are located in the QTL interval on chromosome 4 which regulates the expression of F2rl1. Only genes with an expression signal larger than 8 were selected. Table S12 Candidate genes located in the QTL interval on chromosome 2 (autoimmunity to DNA). The table lists probesets of possible candidate genes that are located in the QTL interval on chromosome 2 which regulates autoimmunity to DNA. Only genes expressed in Treg cells (signal > 8 on log2 scale) and exhibiting a cis-eQTL of LRS > = 15 were selected.

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Alberts et al. BMC Genomics 2011 12:610   doi:10.1186/1471-2164-12-610