Research article

Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances

Ariel Fernández^1,^2,³^*, Yun-Huei Tzeng⁴ and Sze-Bi Hsu⁵

¹ Instituto Argentino de Matemática “Alberto P. Calderón”, CONICET (National Research Council of Argentina), Buenos Aires, 1083, Argentina

² Department of Computer Science, The University of Chicago, Chicago, IL 60637, USA

³ Morgridge Institute for Research, Madison, WI 73715, USA

⁴ Graduate Institute of Biostatistics, China Medical University, Taichung 40402, Taiwan

⁵ Department of Mathematics and National Center for Theoretical Science, National Tsing-Hua University, Hsinchu 300, Taiwan

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BMC Genomics 2011, 12:604 doi:10.1186/1471-2164-12-604

Published: 14 December 2011

Additional file 1:

Non-singleton gene families in yeast, worm, fly and human with coding regions able to sustain free subunits with ordered structure.

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