Identification of Rrp44 protein catalytic potential in Giardia. Alignment of E. coli RNase II with Rrp44 amino acid sequences from G. lamblia (G.l.), S. cerevisiae (S.c.), and H. sapiens (H.s.) show levels of high conservation. Important regions required for RNA binding are underlined. Dark gray represents amino acid identity while the light gray represents amino acid similarity. The conserved amino acids in the catalytic pocket of E. coli RNase II are noted by an asterisk above the sequence.
Williams and Elmendorf BMC Genomics 2011 12:586 doi:10.1186/1471-2164-12-586