Table 1

GO categories enriched in microarray comparisons through gossypol-tissue treatments

GO accession

GO term

Corrected p-value


T7- Gut/UP

GO:0055114

oxidation reduction

7.19E-19

GO:0016491

oxidoreductase activity

1.94E-18

GO:0044429

mitochondrial part

4.01E-15

GO:0005739

mitochondrion

2.28E-14

GO:0005740

mitochondrial envelope

1.50E-10

GO:0031966

mitochondrial membrane

2.77E-09

GO:0003824

catalytic activity

6.22E-08

GO:0031967

organelle envelope

6.77E-08

GO:0005743

mitochondrial inner membrane

7.14E-08

GO:0019866

organelle inner membrane

7.76E-08

GO:0031975

envelope

5.36E-07

GO:0031090

organelle membrane

7.13E-07

GO:0044444

cytoplasmic part

6.98E-05

GO:0015992

proton transport

7.52E-05

GO:0006818

hydrogen transport

8.16E-05

GO:0006091

generation of precursor metabolites and energy

8.16E-05

GO:0042180

cellular ketone metabolic process

1.27E-04

GO:0015077

monovalent inorganic cation transmembrane transporter activity

3.16E-04

GO:0019752

carboxylic acid metabolic process

3.50E-04

GO:0043436

oxoacid metabolic process

3.50E-04

GO:0006082

organic acid metabolic process

3.50E-04

GO:0005759

mitochondrial matrix

4.27E-04

GO:0031980

mitochondrial lumen

4.27E-04

GO:0008610

lipid biosynthetic process

4.81E-04

GO:0015672

monovalent inorganic cation transport

4.81E-04

GO:0005506

iron ion binding

7.97E-04

T5 - Rest of body/DOWN

GO:0007156

homophilic cell adhesion

1.90E-05

GO:0016337

cell-cell adhesion

2.83E-04

T7 - Rest of body/DOWN

GO:0070003

threonine-type peptidase activity

4.38E-12

GO:0051603

proteolysis involved in cellular protein catabolic process

3.93E-14

GO:0051444

negative regulation of ubiquitin-protein ligase activity

3.99E-05

GO:0051443

positive regulation of ubiquitin-protein ligase activity

1.12E-04

GO:0051439

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

1.12E-04

GO:0051438

regulation of ubiquitin-protein ligase activity

1.12E-04

GO:0051437

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

1.12E-04

GO:0051436

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

3.99E-05

GO:0051352

negative regulation of ligase activity

3.99E-05

GO:0051351

positive regulation of ligase activity

3.00E-04

GO:0051340

regulation of ligase activity

3.00E-04

GO:0044265

cellular macromolecule catabolic process

2.67E-11

GO:0044257

cellular protein catabolic process

3.93E-14

GO:0043632

modification-dependent macromolecule catabolic process

5.52E-10

GO:0043234

protein complex

2.38E-08

GO:0043161

proteasomal ubiquitin-dependent protein catabolic process

1.12E-04

GO:0031398

positive regulation of protein ubiquitination

1.86E-04

GO:0031397

negative regulation of protein ubiquitination

3.99E-05

GO:0031396

regulation of protein ubiquitination

4.83E-04

GO:0031145

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

3.99E-05

GO:0030163

protein catabolic process

8.38E-17

GO:0022624

proteasome accessory complex

4.28E-08

GO:0019941

modification-dependent protein catabolic process

5.52E-10

GO:0019773

proteasome core complex, alpha-subunit complex

8.26E-04

GO:0010498

proteasomal protein catabolic process

1.12E-04

GO:0009057

macromolecule catabolic process

3.09E-09

GO:0006511

ubiquitin-dependent protein catabolic process

4.88E-10

GO:0006508

proteolysis

1.86E-04

GO:0005839

proteasome core complex

4.38E-12

GO:0005838

proteasome regulatory particle

6.90E-09

GO:0004298

threonine-type endopeptidase activity

4.38E-12

GO:0000502

proteasome complex

2.60E-29

T7 - Rest of body/UP

GO:0016491

oxidoreductase activity

9.14E-24

GO:0055114

oxidation reduction

7.45E-20

GO:0042302

structural constituent of cuticle

6.83E-13

GO:0050662

coenzyme binding

1.18E-12

GO:0048037

cofactor binding

1.18E-12

GO:0050660

FAD or FADH2 binding

1.16E-08

GO:0003824

catalytic activity

3.37E-08

GO:0006066

alcohol metabolic process

2.52E-07

GO:0016614

oxidoreductase activity, acting on CH-OH group of donors

2.52E-07


Statistically filtered transcriptional responses per H. armigera tissue (Welch's t-test, B&H FDR corrected P < 0.001) relative to gossypol-free diet expression data was subjected to GO enrichment analysis (P < 0.01) using Agilent GeneSpring GX11.5.1 software (Gossypol concentration: T5 = 0.016%, T7 = 0.16%).

Celorio-Mancera et al. BMC Genomics 2011 12:575   doi:10.1186/1471-2164-12-575

Open Data