Open Access Research article

Sex-dimorphism in Cardiac Nutrigenomics: effect of Trans fat and/or Monosodium Glutamate consumption

Kate S Collison1*, Marya Z Zaidi1, Zakia Maqbool1, Soad M Saleh1, Angela Inglis1, Nadine J Makhoul1, Razan Bakheet1, Mohammed Shoukri2 and Futwan A Al-Mohanna1

Author Affiliations

1 Cell Biology & Diabetes Research Unit, Department of Biological & Medical Research, King Faisal Specialist Hospital & Research Centre, PO BOX 3354, Riyadh 11211, Saudi Arabia

2 Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital & Research Centre, Saudi Arabia

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BMC Genomics 2011, 12:555  doi:10.1186/1471-2164-12-555

Published: 12 November 2011

Additional files

Additional File 1:

Figure S1. Histology of cardiac tissue. A: transverse section and B: longitudinal sections of hematoxin and eosin-stained cardiac tissue from mice in control, MSG, TFA and TFA+MSG diet groups. Scale is x790.

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Additional file 2:

Table S2a. Differentially expressed cardiac genes in males compared to females (p ≤0.01) with a fold change of ≥ 1.5. Table S2b. Differentially expressed cardiac genes in females compared to males (p ≤0.01) with a fold change of ≥ 1.5.

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Additional file 3:

Table S3. Gene ontologies & pathways enriched for differentially expressed genes comparing all males to all females.

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Additional file 4:

Table S4. Differentially expressed genes in either males or females for the comparison TFA vs Control with respect to diet and sex (P < 0.01) and fold change ≥ ± 1.5.

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Additional file 5:

Table S5. Differentially expressed genes in either males or females for the comparison MSG vs Control with respect to diet and sex (P < 0.01) and fold change ≥ ± 1.5.

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Additional file 6:

Table S6. Gene ontologies enriched for differentially expressed genes comparing MSG to Control diet in males and females.

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Additional file 7:

Table S7. Differentially expressed genes in either males or females for the comparison TFA+MSG vs TFA with respect to diet and sex (P < 0.01) and fold Change ≥ ± 1.5.

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Additional file 8:

Table S8. Gene ontologies enriched for differentially expressed genes comparing TFA+MSG to TFA diet in males and females.

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Additional file 9:

Table S9. Intensities of genes/ESTs differentially regulated only in males with a fold change of ≥ ± 1.5 for either of the comparisons Control vs MSG, Control vs TFA, or TFA vs TFA+MSG.

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Additional file 10:

Table S10. Intensities of genes/ESTs differentially regulated only in females with a fold change of ≥ ± 1.5 for either of the comparisons Control vs MSG, Control vs TFA, or TFA vs TFA+MSG.

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Additional File 11:

Table S11. Primers for genes selected for confirmatory QRT-PCRs.

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