Coefficients of correlation between replicability and FST for the 890 associations from the Global Set. Values correspond to Spearman correlation coefficients (ρ). The replicability is measured in % of positive studies over total studies and the genetic differentiation values correspond to average FST values between Europeans and East Asians, under different pooling conditions. X-axis values indicate the cutoff of number of studies per associations, filtering out those associations with fewer studies than indicated. Solid grey lines correspond to the Full Set of associations. Dashed lines correspond to associations from the Conservative Set (replicability ≥50% in at least one continent). Circles, triangles and squares correspond to FST values computed from average of the SNPs in a gene, individual SNPs and tagSNPs, respectively.
Marigorta et al. BMC Genomics 2011 12:55 doi:10.1186/1471-2164-12-55