Evolutionary histories of neighbour regulators and their nearby target genes. Shown here is a schematic representation of 93 regulatory neighbourhoods. Genes encoding TFs are represented as circles and the corresponding nearby target genes of the TF as squares. Genes are coloured accordingly: non-LGT genes are red, ORB+ genes are dark blue, ORB- genes light blue and genes for which LGT information is not available are white. 'Non-LGT' refers to gene sets that yielded a phylogeny that was concordant with the E. coli - Shigella reference tree and had no recombination breakpoints within the gene boundaries.
Skippington and Ragan BMC Genomics 2011 12:532 doi:10.1186/1471-2164-12-532