Table 3

Top Canonical Pathways for gene-associated probes that show variable methylation within each gestational age

Variable in First trimester

p-value

genes


Arachidonic Acid Metabolism

6.97E-04

CBR1, CYP2E1, GPX7, PNPLA3, PTGS1


Hepatic Fibrosis/Hepatic Stellate Cell Activation

1.36E-02

CYP2E1, ECE1, FGFR1, MYL5


Circadian Rhythm Signaling

1.91E-02

GRIN3A, VIPR2


Calcium Signaling

2.69E-02

CHRNB4, GRIA4, GRIN3A, MYL5


Nitrogen Metabolism

3.54E-02

PTPRG, VNN3


Variable in Second trimester

p-value

genes


Circadian Rhythm Signaling

3.39E-03

GRIN3A, VIPR2, PER1


Glutathione Metabolism

1.62E-02

GPX3, GPX7, GSTO1


Arachidonic Acid Metabolism

1.86E-02

CBR1, CYP2E1, GPX3, GPX7


Sonic Hedgehog Signaling

3.7E-02

DYRK1B, HKR1


Metabolism of Xenobiotics by Cytochrome P450

4.68E-02

ADHFE1, CYP2E1, GSTO1


Variable in Third trimester

p-value

genes


Glutamate Receptor Signaling

6.1E-03

GRID2, GRIK2, GRIN3A, GRM6, SLC1A6


Valine, Leucine and Isoleucine Degradation

1.13E-02

ACADL, ALDH1A3, ELOVL2, IVD, OXCT1


β-alanine Metabolism

2.07E-02

ACADL, ALDH1A3, DPYS, IVD


Butanoate Metabolism

3.74E-02

ALDH1A3, ELOVL2, OXCT1, PDHA2


Tyrosine Metabolism

4.19E-02

ADHFE1, ADLH1A3, ELOVL2, MGMT


Novakovic et al. BMC Genomics 2011 12:529   doi:10.1186/1471-2164-12-529

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