Additional file 6.

Proportion of probes within a particular methylation level. Pie Charts showing the proportion of probes within a particular methylation level for first, second and third trimester. The percentage of probes with a 'β < 0.02' is the same in all three gestational ages (63%), suggesting that probes with low methylation in first trimester remain low over placental development. Furthemore our data suggests that probes with an intermediate methylation in first trimester are the ones that increase over gestation, with a lower proportion of probes in the 'β = 0.2 - 0.6 group' in second (22%) and third (20%) compared to 1st trimester (24%); and a higher proportion of probes in the β > 0.6 group in 2nd (15%) and term (17%) placenta compared to 1st trimester (13%).

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Novakovic et al. BMC Genomics 2011 12:529   doi:10.1186/1471-2164-12-529